Analysis of Oxoglaucine in the Treatment of Breast Cancer Based on Network Pharmacology and Bioinformatics

To explore the potential molecular mechanism of Oxoglaucine(OG) in treatment Breast Cancer(BC) based on network pharmacology and bioinformatics. TCMSP SwissTargetPrediction databases search for OG Related targets, GeneCards database finds all BC-related targets. Take intersection BC as targets that inhibit BC. All are topologically analyzed by Cytoscape 3.7.1 software, finally core target is obtained. The start analysisi function DAVID performs bioinformatics analysis further visualizes them with help R language tools. As a result, 104 were obtained, which SRC, PIK3CA, EGFR, MTOR, ESR1, MAPK1, PTGS2, AR, NOS3 main inhibits occurrence through Pathways cancer, PI3K-Akt signaling pathway, Proteoglycans ErbB HIF-1 pathway related pathways, mainly involving signal transduction, protein phosphorylation, negative regulation apoptotic process, positive transcription from RNA polymerase II promoter, phosphatidylinositol-mediated biological processes. This study initially reveals inhibiting BC, provides reference research.